It is a state of mind in which you will be confused to the point where your brain will go into an "overdrive". Your mental resources will go into an overload in exchange for loss of coordination, focus, and possibly manhood.
Your brain will then violently implode, and cease to exist, possibly summoning an infamous black hole.
"Holy crap, I slapped the booty of Jack's girlfriend, and I think he got confurzgled!"
"Dude, that girl's behaviour is pushing me to the brink of confurzgledia!"