Cocktail Lobotomy Share definition Flag Being extremely drunk and being very happy. On the way to blackout city. "Look at Joe over there, he's drank so much that he's had a cocktail lobotomy" Cocktail Lobotomy by Zven January 30, 2009 0 0 Get merch Get the Cocktail Lobotomy mug. Buy Now — $32.95 See more merch