The disease of being so good looking and charming, Much like George Clooney that women actually assume you are only out to have sex with them. Thus, limiting the number of women you actually get to have sex with.
Sufferers of Clooney Syndrome include:
George Clooney
Matt Lauer
Winston Spivey
Johnny Depp
by Spivs September 14, 2008
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man who is secretly taking over the world one movie at a time...
person one: have you seen the new george clooney movie??
person two: no
person one: why not?!?!?!?!!
person two: because he is trying to take over the world
person one: oh
by Alli111 June 4, 2006
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When a woman you are dating becomes annoying and controlling, you have crossed The Clooney Line. It is time to move on and find another. The Clooney Line was developed by George Clooney. It typically takes about 6 months to reach this line in most relationships.
My girl is constantly bitching and we haven't had sex in 10 days...... Damn, I think I crossed The Clooney Line!!!
by The Gootz August 30, 2014
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When a guy is too good looking and intimidates any surrounding social group. The guy is considered to be so good looking (like the actor George Clooney) that he has a hard time getting woman to trust him because they think he's a player. Also the men around him get jealous and try to push you out of the social group with drama so they have a better chance with the women in the group.
Girl: "Hey, I don't get a good vibe from him, he's very handsome and I think he's a player"

Girl2: "Yea, he suffers from the Clooney Effect, give him a chance though... don't judge too quickly."
by DragMeToHell May 28, 2009
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1. A drunken person that is anything BUT Irish, acting like an asshole on St. Patty's day. He must be wearing green, intoxicated, and behaving like a fucking asshole.
Bloke#1 "Who is that arsehole over there?"
Bloke#2 "Some fuckin' wanker"
Bloke#2 "Hey, buddy what is your fuckin' name?"
Asshole "It's St. Patty's Day, Today my name is now Clooney!"
Bloke#1 "Clooney, eh? How about Dickless Clooney! You fucking wanker! Get the fuck out of my fucking face!"

1 hour later
Bloke#2 screams at some drunk Assholes dressed in green "You fucking Dickless Clooney!"
by Anon-in-Il-Again March 4, 2008
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A man who is terribly attractive. Saying so little is like making him an equal with Brad Pitt, which is so unfair. The truth of the matter is that George Clooney is much more than good-looking. He is the man. He doesn't look 42 because he was actually born in 1961, which would make him a little older. Which means he looks amazing for his age. Not that he's old. George has captured audiences with his charm and humor. He gets viewers' attention seemingly effortlessly. A film with his name can not help but do well.
Who wouldn't marry George Clooney?
by A. Anonymous January 28, 2008
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