An initial exclamation of exasperation. When something is not going the way it should, and heavy frustration occurs, calling upon the subject of this explanation may appear to be, to some, the only answer. Similar to "For God's Sake", "For Pete's Sake" or "For Fuck's Sake".
Christ Almighty, what did I do to deserve this?
Christ Almighty, she never did... did she?
Christ Almighty, Sat, will you please just Fuck off?
Christ Almighty, where are you when I need you?