CHX-Br is short for cyclohexyl bromide (or CycloHeXyl Bromide). Cyclohexyl bromide can react with sodium ethoxide (NaOEt) and ethyl acetoacetate (EAA) to form Ethyl 2-cyclohexyl-3-oxobutanoate. Then react with hydrochloric acid to get 2-cyclohexyl-3-oxobutanoic acid. Heating it up will get you Cyclohexyl-2-Propanone (CHX2P, Cyclohyxylacetone) , a useful intermediate in the synthesis of Propylhexedrine, and carbon dioxide as a side product. Propylhexedrine is good orally in doses of 60mg to 180mg+ to decongest the nose, as a pre-workout, and to lose weight. Cyclohexyl bromide can also undergo other chemical reactions such as turning it into Cyclohexyl magnesium bromide and reacting it with Propyl chloride to get 1-cyclohexylpropane (unless there's rearrangement to 2-cyclohexylpropane).
Tony: I synthesized Cyclohexyl-2-Propanone (CHX2P) using CHX-Br and ethyl acetoacetate.
by CognitiveFuel July 7, 2023
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