Top Definition
noun: A Gargantuan fat chick, usually unkempt and smelly and frequently of foul temperament.

The kind of woman that Buffalo Bill hunts.

See also Buffalouis
"There was a Buffalola sitting next to me at the bar. She needed a bar stool for each of her ass cheeks."
by The Afterworld Cafe July 03, 2005
2 Words related to Buffalola

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