3.
Most hilarious line ever, and a way to vent anger when your friend rejects an outing (usually a pathetic excuse) cause your bored as fuck and stuck at your house all weekend. Originated from the movie Mean Girls when Karen rejects hanging out with Regina because she called her a slut.

The famous quote:
Karen: I can't go out, *cough cough* i'm sick.
Regina: Boo, you whore! *hangs up*
Karen: :O
Another example of an annoying whoebag who ruins your weekend:
Girl 1: Hey, wanna hang out tonight? I'm so bored.
Girl 2: Nahh, i'm too tired... srry. mybe ltr ;)?
Girl 1: boo, you whore!
*signs off*
by monty554 December 12, 2011
 
1.
Way of expressing displeasure towards a rejected offer.
Mean Girls:
Karen: I can't go out.
(fakes cough)
Karen: I'm sick.
Regina: Boo, you whore

-Want to split a pitcher?
-Can't, I'm driving.
-Boo, you whore.
by LeadTrigger June 05, 2007
 
2.
a quote from the film 'mean girls' where regina used sarcasm to describe the ways she felt about karen being 'sick' which is obvious by her use of the words "you whore" after "boo"
THE QUOTE:
Karen: I can't go out.
(fakes cough)
Karen: I'm sick.
Regina: Boo, you whore.
by justine justine December 08, 2007

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