The instance of a guy losing his boner due to whatever circumstance (usu. under sexually disappointing conditions).
Derrick: "So, my chick friend introduced me to Martha, the school hottie. She's got huge tits, beautiful legs, and wonderful locks of hair."

Dan: "You think you have a chance at tappin' that?"

Derrick: "Well, turns out Martha is a tranny. Just remembering she has a penis results in my immediate bone loss."
by Jacktup24/7 January 27, 2012
Get the Bone Loss mug.