To wreak havoc on a toilet (preferably someone else’s) by taking a monster shit, often of the explosive diarrhea variety, with extreme force. Past tense: Blew up the Can.
Jay: “Every time I go over to Ethan’s house, I blow up the can after dinner. I don’t think his parents are ever gonna let me come back again.”

Larry: “Susan let me stay over last night and this morning I totally blew up the can. Now she won’t return my calls.”
by Mr Mucho Macho October 25, 2020
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When you mess up and reveal something that you weren't supposed to
"Dude, why did you tell the cops?! You totally blew the can!"

"Don't leave fingerprints behind, you don't want to blow the can on our operation."
by Canblower76 November 8, 2022
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