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Biggie Smalls syndrome

When one womans breast is larger than the other.

Yo mama got one big titty and one little titty, they call the bitch biggie smalls! - Biggie Smalls syndrome

by Chips and subs November 15, 2010

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Biggie Smalls Syndrome

When a woman has one breast larger than the other.

Amy is getting a boob job to cure her biggie smalls syndrome.

by El_Karnicero January 31, 2008

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Biggy Smalls Syndrome

A female consisting of a fat ass and no tits.

"Hey Ricky, dating that chick that has Biggy Smalls Syndrome will ultimately lead to your downfall."

by T.L. July 5, 2005

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