In Texas Hold'Em, it is commonly referred to when holding a King and an Ace. It is called such because it is a sweet, sweet hand, but can cause a bit of a toothache.
"Whoa Burt, I just ran my Big Sugar into pocket Aces! I was sure I had the best hand!"

"That Donk had a 25 against my Big Sugar!"
by HMFD November 8, 2007
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The sugar industry.

The term formed as a direct comparison to “Big Tobacco” because both industries are shady, fiendish and a major threat to public health.
Big sugar has us right where they want us
by IbreathAir February 24, 2021
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Typically refers to wealth. In particular, in the form of liquid assets.
I'll be getting big sugar from my tax return this year.
by Quajupeg March 17, 2006
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