2 more definitions
Best Teacher Friend Forever
Mr. Johnson and I sometimes hang outside of class. He's my BTFF.
by Mr. Johnson's Daughter November 02, 2013
Best Friends made through the diagnosis of brain tumors. Brain Tumor Friends Forever!!
I met Nikki and Melissa thru the brain tumor association and it didn't take long for us to be BTFF.
by ChickenMuscles June 03, 2010