look up any word, like dirty sanchez:
 
3.
Be the fuckung friend.
btff Be the fucking friend
by porno fonen April 28, 2004
 
1.
Best Teacher Friend Forever
Mr. Johnson and I sometimes hang outside of class. He's my BTFF.
by Mr. Johnson's Daughter November 02, 2013
 
2.
Best Friends made through the diagnosis of brain tumors. Brain Tumor Friends Forever!!
I met Nikki and Melissa thru the brain tumor association and it didn't take long for us to be BTFF.
by ChickenMuscles June 03, 2010