look up any word, like lemonparty:
 
2.
Best Friends made through the diagnosis of brain tumors. Brain Tumor Friends Forever!!
I met Nikki and Melissa thru the brain tumor association and it didn't take long for us to be BTFF.
by ChickenMuscles June 03, 2010
 
1.
Best Teacher Friend Forever
Mr. Johnson and I sometimes hang outside of class. He's my BTFF.
by Mr. Johnson's Daughter November 02, 2013
 
3.
Be the fuckung friend.
btff Be the fucking friend
by porno fonen April 28, 2004