Ambidextrimousous Share definition Flag The ability to use a computer mouse accurately using either the left hand or the right hand. I am ambidextrimousous because I use a mouse with my left hand at work and my right hand at home. Ambidextrimousous by Savane September 4, 2010 0 0 Get merch Get the Ambidextrimousous mug. Buy Now — $32.95 See more merch