an offshoot of swamp ass, murder in the swamp ass is when a girl is on her period and is also sweating buckets from summer heat
Sheila was quite agitated walking 32 NYC blocks with murder in the swamp ass.
by marilefay August 18, 2010
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A massive headache or real pain in general. Something ultra annoying to deal with altogether.
I tried opening a new bank account yesterday at Wells Fargo. Wells Fargo is a murder in the ass. They constantly lock my account if I get my password wrong more than twice and I can’t fix it until I call or go into one of there branches.
by OrangeCandyBar April 26, 2022
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