Top Definition
a simple code to express extreme displeasure with someone. Alphabetic code numbered 1 to 26. In this case the illustrious F-U.
6-21 former coach of the red and gold California football team.

Hey, criminal elected leader of the free world, 6-21!
by Imtalkinhere December 18, 2014
1 more definition
2 Words related to 621
Short form of "six to one," which is in itself a short form of "six to one, half dozen to the other."

Used to indicate apathy towards a given either/or choice.


"damned if you do, damned if you don't"

Q: You want Bud Light or Miller Lite?

A: Doesn't matter: it's 621.
by sam May 06, 2004

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