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From "to excess" but stronger: e.g. way over-doing something; manic; out of control; drunk; toxic; dangerous.

It can be used in a variety of ways depending on context.
She isn't dressed for success, she's dressed 2xs.
Y'all better ask somebody: you think you're loc, but he's 2xs!
I'm going 2xs--don't wait up.
by tommcatt January 01, 2010