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3.
two punches in rapid succession with alternating use of both fists
She Gave him a 1-2 punch that knocked his lights out.
by The Return of Light Joker April 30, 2009
 
1.
A system for getting a woman to preform various sexual acts on you. It is initiated by a woman complementing a part of your body such as your hairstyle. This should immediately be followed by "whipping it out". The 1-2 punch may sometimes be considered sexual harassment or public indecency.
Girl: Hey, your hair looks nice today.

You: If you like that, then check this out.

*You whip it out*

You: The 1-2 Punch: works every time.
by McNubbin42 December 18, 2009
 
2.
The act of two people doing sexual things with a girl simuntaneously. Sort of like a gangbag or doubleteam. Other definition would be 1 guy starting to have sex with a girl, then pulls out and has the other guy finish her off.
"Would you like to experience the old 1 2 Punch"
by Bballftw123 December 16, 2009
 
4.
The act of passing out after having taken only two hits of (usually) high-potency weed.
That shit was so potent it gave him a 1-2 punch. The guy was out cold on the floor!
by Stop the Pendulum February 18, 2006