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Threadmill 

He is exhausted from running on the threadmill of life.
Threadmill by bellagio99 February 18, 2011

Tiredful 

Exhausted of strength or energy; fatigued.
Today was so tiredful
Tiredful by James Miller March 10, 2021

threadkill 

threadkill

to put a negative or stupid comment on a persons facebook thread. Particularly when the topic or "thread" is upbeat and funny. A threadkill will usually bring a halt to the conversation. A threadkill can be used as a noun or a verb.
facebook topic starts: What a great day the weather is awesome
Comment 1: gorgeous 80 and sunny
Comment 2: We have a little rain but life is good!
Threadkill: I can't go outside ever because I get sunburned and I have allergies
threadkill by simonayes May 12, 2010

threadzilla 

An email thread involving 5 or more people who, when they all respond, the thread becomes longer, more difficult to accomplish the task at hand, and just generally monstrous. The more people respond, the worse it gets.
"This email thread has so many responses we aren't getting anything done."

"Time to get everyone on a conference call and quit screwing around with this threadzilla so we can get this resolved."

Treadfull 

When riding ones motorcycle and you accidentally ride through Dog Shit
I've had a treadfull today since I hit all that shit!
A banging tune that you need to dance to with your friends.
"Grace get over here, there's a FUCKING treadflop about to come on"
treadflop by Lulucott April 20, 2017