When you microwave your fuckn weed and then open the microwave.
"I put my joint in a windowsill so my parents wouldn't find it, and it froze overnight. So I microwaved it to soften it up and when I took it out of the microwave it was like opening Pandora's Box."
by December 4, 2020
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The effect that transcends one's curiosity into an overactive drive/need to experience something, regardless of the ending possibilities. It is different from peer pressure since it does not require external forces, but is similar to physiological effects, such as being horny.
A: I think I wanna get a prostate exam, just to see what it's like
B: That's the Pandora's Box Effect, dude. Don't fall for it.

A few days later

A: I got a prostate exam.
B: You look a little different.
A: You think?
by NTRP January 6, 2021
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Shooting up yourself is kind of like opening Pandora's box.
by M0n$t3r August 18, 2014
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When your homie starts playing that one radio station that you can't stand just to piss you off and you end up beating his ass
Man, ed kept playing that damn nickleback station so I started pandora boxing him till he quit
by GrimThaReaper December 26, 2017
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In Project Zomboid, Pandora's Box means when you open a door of any building and a horde of zombies appears after you open it. catching you off guard and most likely resulting in your death
Person: "Damn, all 4 of us died because we opened Pandora's Box." (Louisville Grand Ohio mall)
by Zepherixs August 17, 2023
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