1. For Sure, My Nigga'. Commonly played out by snoop dog and other rap artists. Found Irefuetably aggravating for the southern , blue collared working class, white american.
Fo Shizzle Ma Nizzle, lez go smokkee some weedz
by matt June 8, 2004
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used as an alternative to "fuckin hell!" or "fuck me!" when feeling shocked or startled.
well shizzle ma nizzle, this is sum strong shit!!!
by Baggott December 13, 2006
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Bodan: "you gonna come kick some white ass tonight?"
Rajib: "fo shizzle ma nizzle, im there!"
by harv1989 October 24, 2006
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This is not a word, period. It is some silly bullshit perpetuated my Snoop Dogg or P. Poodle or whatever he is calling himself this week. However, if you really want to judge it to the same standards as real words, it loosely means "Okay".
"Excuse me sir, do you have any Grey Pupon?"

"Fo shizzle ma nizzle!"
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Def: Absolutely positively 100% accurately correct my brotheren
It is derived from the ancient swahili tribal word in Africa --"FASHIZCHMANICLE"
It is only appropriate for black/colored people to use this term because they have black penis
by jeff jefferson March 22, 2005
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1. a bastardization of for sure my nigga
2. has nothing to do with sex/getting some
by sah January 31, 2003
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