When you fuck Marc Antonio Pio and turn to a freak and love his dick
Yo bitch: I just fucked Marc

Yo sister: you got the Pio affect
by Big spill January 27, 2019
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It’s a man who loves Chicks (Pio pio pio)
It is also used with Porco Dio
Padre Pio, Porco Dio!
by rubenistian November 2, 2022
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The craziest motherfucker on the road, He will do anything to beat you in a street race. Likely to get in a crash and chronically plays 2-step as the only song while he's driving because it has excessive bass to it.
He is a jay pio driver in that young Prius.
by Chief Sosa December 5, 2012
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Being a bi*ch, scared of p***y.
Wow that dudes really being a pio rn, idk why he’s not spitting game
by Norfnick2043 February 9, 2021
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A bastard stalker that goes to ICA Manila and keeps harassing my friends.
by FVCKYOUPIO!! August 29, 2023
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It's an oftenly word used in the drawception website, and are the initials of the word "Pass it on"
- "draw your favourite character PIO"
-"something cool PIO"
by AngryadamfightTV September 23, 2017
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