when one has a bowel movement and proceeds to wipe and there is no fecal matter on the toilet paper, thus finishing the activity with one wipe similar to a home run in baseball, scoring with one swing of the bat, similar to a ghost wipe.
I just dropped a fat deuce and it was a home run!
by NOR CAL NINJA March 8, 2006
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When you do everything on one date.
You go to first, second, third and 4th base.
I hit a home run with her.
by Gujuunit February 21, 2005
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When hitting a baseball into your girlfriend's asshole with a bat. Then crouch until she shits it out and then catch it in your mouth.
My girlfriend will do some crazy stuff, she'll even do a home run!
by OVER 9000 OVER 9000 September 26, 2010
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A humorous addition to any sentence. First made appearance in Halo 3 2: Halo 4 The Movie (available at Newgrounds)
"I mean we're gonna HOME RUN for it!"

"Show yourself home run!"

"Sounds like a bunch of mumbo-jumbo to me, home run."

"Be well, be well... home... ruu..."
by Allen Johnson March 13, 2006
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When you let you significant other touch you on you 'bases' then after they get caught not playing fair. They Strike out and you never she them again.
Man, I cannot believe she made a Home Run with my cousin and my friend.
After I let her touch my bases.
by The Other Trooth June 26, 2014
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When guys, or girls, brag about getting a lucky home run, they ain't talking about baseball. They're usually referring to how they ran through the bases on a one night stand; First base, Second base, Third base, Fourth base, and yeah, that's right, Fifth base, baby! ;)
Guy 1: Dude, i just ran a Lucky Home Run: on the first date!
Guy 2: Sweeeet!!
by ForgeousChic101 July 24, 2011
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An orgy, or any occasion where lots of sexual intercourse is being had.
Last night's home run derby really tired me out, that was a lot of scoring!
by rhank April 16, 2008
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