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A woman who interferes with a friendship.
Generally, one male seems to love her,
And the other seems to hate her.
Usually, fights occur between the two friends.
Originated from the Ono-Lennon-McCartney conflict.
John Lennon and Paul McCartney had a very strong bond, Yoko came along, and BAM the Beatles broke up. They had had building tension..but Yoko Ono pretty much brought on the final load.
Friends script:
(David is feeding Phoebe popcorn. Max walks up)
Phoebe: Hi, Max!
Max: Yoko. (To David) I've decided to go to Minsk without you.
David: Wow.
Max: It won't be the same- but it'll still be Minsk. Happy New Year. (Walks off)
yoko by Cardboard.canvas May 26, 2006
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a BIG girl who is unattractive and unlikely to get any attention or action, unless she takes advantage of an unlucky fellow who had consumed too many alcoholic beverages. the name "yoko" derived from the famous professional wrester from the '80s named Yokozuna.
"damn man last night was crazy, Jose hooked up with a yoko."

"yokos need love too."
Yoko by takeiteasypaulweezy September 13, 2012
Related Words
A person (usually female) who breaks up a group of friends or a good relationship with a person.
Jesse: Have you seen Andrew?
Cody: He's with that Yoko, April.
Jenny: Bitter, yet true, Cody.
yoko by Darth_`Eowyn December 18, 2006
n. a bitch girlfriend who doesn't let you chill with your boys
derived from Yoko Ohno, the wife of John Lennon, who single-handedly broke up the Beatles
"Where's he tonight?"
"Chillin with Yoko, she wouldn't let him come out"
Deserting your friends/band mates/organization for your new found love or significant other.
pulling a Yoko: "Man we were doing so good and then he had to go and pull a Yoko"
Yoko by Zaphod May 26, 2004
A girl with a sniper rifle, usually with boobs bigger than the national debt
Kamina: hey simon who's that girl with the huge tits?
Simon: bro that's yoko
Yoko by Animepancake November 9, 2014
In verb form:
To royally screw up a band. (Usually applies to a woman/man who screws up the band because she/he is screwing a band member.)

In Noun form: The said band screwer-upper.
Verb:
Person 1: I used to like their band, what happened?
Person 2: Lead singer got Yoko'd and it all went down hill from there.

Noun:
Person 1: What's up with lead singer?
Person 2: See that girl hanging off him? That's what.
Person 1: Dammit Yoko, stop screwing up the band!
Yoko by Lord of the Ping July 16, 2007