A word commonly used in substitute for girlfriend, or lover.
"sorry dude, i cant go clubin' tonight, im chillin' with the Main Squeeze."
by Kenny Koston September 29, 2011
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1. Your closest friend or friends

2. Boyfriend or girlfriend
Person 1:"These people right here are my main squeeze fo life!"
Person 2:"That's cool,"

Guy: "will you be my main squeeze?"
Girl: "of course!"
by LNBerger August 24, 2010
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shwayze-corona and lime
baby, will you be my corona and lime?
and i will be your main squeeze

and if your brother dont like my style, we can take it to the street
we can take it to the street
by KirstieM July 26, 2008
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your best friend or "bro". usually used between guys
person1: who's your best friend?
person2: Jon.... He's my MAIN SQUEEZE.
by d.so February 12, 2011
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Not your boy/girlfriend but they come before everyone else. You both have feelings for each other but your not dating. You still look at other people but there just your number one friend
Tom: who’s that girl your always around
Jay:oh that’s just my main squeeze
by Nyccc38 January 20, 2020
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