When something surprising with a huge magnitude happens (IE: Pregnancy, The rapture, and/or Bon Jovi making a serious comeback) this phrase is used to express disbelief
Man #1-Hey did you hear the latest Nickel back song, its pretty good

Man #2- Holy Sweet Jesus Shit a GOOD nickelback song? Must investigate further.
by The Shephard April 3, 2009
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An exclaimation, generally used to describe either something surprising or something extremely cool, radical, awesome, or any other adjective from the Ninja Turtle vocabulary.
"Oh my fucking sweet jesus tits! Check out those...tits!"
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