Jeff:Takes ur shield potion in fortnite
You:Whats it like living with ultra down syndrome deluxe?
Jeff:It's alright, I get a lot of free stuff
by Bucket0011 March 27, 2018
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The sexy dance that allows Down Syndromers to have a chance to bone each other!

Steps: Spin, jump, flip, bone!
Come on people, we need to do the Down Syndrome Shuffle!”
by TODDD123456 June 7, 2019
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When a girl goes crazy over a guy, cheats on him, bitches at him, dumps him, and then won't stop brooding about how mean he was to her for the rest of her life. This type of girl is usually also a cock blocker.
Wow, Martha seemed like she had Emily Downs Syndrome last night we she fucked my brother. Megan is inflicted with the terrible Emily Downs Syndrome...I feel so bad for her.
by The Wise Man8587 November 23, 2011
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When two down syndromes experience anal sex for the first time.
Retard #1: Nar-Nar my penis

Retard #2: Hardy har har

This is what we call Down Syndrome Anal Fun
by Bum Killas 101 April 11, 2009
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I'm really surprised at the illiteracy of our society. I think that many people have a learning disability, especially when you ask them what they think Down Syndrome is. It's actually called Trisomy 21. People with this CONDITION (not disease) have an extra chromosome. The 21st chromosome tripled at conception. Most down syndrome people have medical problems such as, heart defects, liver problems and kidney problems. Their weight problems come from their thyroid being too high or too low. These guys can learn, just a little slower than you and I. This is not a disease, it is a condition. They also have features that aren't like ours, which makes them unique. Their not perfect, but neither are we. When you find someone who is, then I think you'd better call the American Medical Association. What makes them much different than some of you that have tried to define this condition is that they are better than you because they have no concept of judgement. You will never hear them judge someone elses way of life. I've read many of the definitions on this site and I can only say that I'm really dissapointed to know that their are that many cruel people out there. YOU rude people are the reason that down syndrome people are rude. They have to protect themselves from people like you. What "DISEASE" do you have that makes you the way you are? These kids are blessed children of God. They don't know what evil is. In closing, the next time you want to create your own definition of something, use your brain and look it up in a dictionary first. As for those of you who bashed this condition, you just made yourself look like a real dumb-ass.
I am a mother of a beautiful little girl who has down syndrome. I can only say to you who down this conditon that you are the ones with a very selfish disease called "JUDGEMENT"
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Post traumatic down syndrome - a condition that mimicks down syndrome that is directly caused by Trauma.
I was diagnosed with post traumatic down syndrome .
by Michelle Gee April 20, 2021
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Describes the man in your group who suffers the worst hangover the morning after.
"OMG, James has Man-Down syndrome. He can't even put his trousers on!"
by nervouspaddy June 15, 2014
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