To be excessively wasted/fucked, be it on alcohol or various other cocktails of drugs.
Tom: Hey man did you see Andy last night at that party?
Ben: Yeah dude that motherfucker was K-cuffed!
by Ben Clarke December 4, 2007
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To have your hands inside two whores asses after a good fisting.
Jim: (calls his friend Jake on speaker) "Jake! I need help man"
Jake: "What's the problem bro?"
Jim: "I brought two strippers back last night and after a good fisting my hands are stuck in their asses!"
Jake: "Oh you're just Ass Cuffed, I'll be right over"
by Ass Cuffed August 12, 2014
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Cuffing's disease is a serious condition in which the patient has attracted a member of the opposite sex in which him/her has no interest whatsoever. Symptoms usually occur within 3 to 4 hangout dates and only worsen as the two people spend more time together. As of now there are no known cures except to "keep it real" from the get go.
Mary: Wow, jenna gave that guy her number last week and they hungout ONCE because she felt bad. Now he won't stop hitting her up.

Liz: Wow looks like she's got a bad case of the cuffing's disease

Ben: damnnn son look at jeff over there with that girl he brought home from minerva last week... they hooked up once and now she's buyin the kid gifts and shift.
Tom: looks like a case of the cuffing's disease
by -you know this August 19, 2011
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a G rated term for FUCKED UP. FUBAR'd
"He drank a case of beer and got cuffed up"
by wbates_6 October 17, 2007
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When you are cuffed up you are using a replacement opiate such as methadone
Suboxone subutex. It is most commonly used to refer to being dependent
On methadone from a clinic. This is because you have to go every day
Unless you stay completely clean then you get one take home dose for every clean
Month I believe you can get a total of 12 take home doses that you need to
Keep In a lock box at all times. On to the other drugs that cause you to
Be "cuffed up" but not nearly as strict is suboxone or subutex. You usually
Have to see your doctor bi weekly and attend group therapy sessions.

You are subject to random drug screens (generally every visit. They gotta get that $)
If you continue to use and come up positive for opiates you are subject
To even tighter restrictions such as weekly visits small prescriptions

For your meds. This in turn usually costs you money if you have insurance
Because it costs the same amount to fill a two weeks supply as it does
For a month. Plus suboxone / subutex aren't all they are said to be. But
Since you have to self administer in the usa you can time your dosing
Schedule so you can get high and be minimally sick usually for no more

Than a few hours.
" hey john did you hear that Jane is saying she is completely clean. But my buddy

Told me he saw jane at the methadone clinic getting her daily sip.

John : wow. I can't believe she has herself cuffed up like that"
by the syringe slammer October 12, 2009
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Cuffing Season- A season in the Autumn and Winter months, Were a woman handcuffs a man of her fancy, And the captured have to do sexual favors for her and/or marry her.
Woman 1: I just Captured a man and made him marry me
Friend: yea?
Woman 1: without a prenup
Friend: You monster!
Woman 1: well its Cuffing Season
Friend: True, Tis the season of physical, and emotional domination over our male counterparts
Woman 1: Amen!
by Shinkdmeister November 4, 2018
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When it's so hot outside that people roll their sleeves up/cuff them.
I have to roll my sleeves up because it's so hot. It must be cuffing season.
by Bgbgbgbg March 9, 2016
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