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A shortened version of the word Motherf**ker. This meaning tho is meant to be non abusive, almost as a sign of respect or greeting for fellow friends..It must be stated tho that the use of the full word is a sing of abuse
Hey Mofo = Aceptable.
Hey Motherf**ker = Abuse
Mofo by rrlwat September 2, 2008
Related Words
A word used instead of mother fucker. It still has the same meaning, but the impact is not as big.

OR

It could be like saying that guy is the shit!
Billy Bob: Goddammit! I wanna fuck something up! That fucking mofo stole my fucking wallet!! Shit man!

OR

Sally Sue: Damn, you be tite for dating that mofo!
mofo by I Luff Yooh Bitches January 5, 2009
1) motherfucker
2)niall horan used this to call his fans crazy mofos
mofo by stakia March 10, 2018
Damn, that mofo is stealing the bank. Where are the shithead cocksucking police dicks!?!?!?
MoFo by Anonymous February 25, 2003
1. Short version of the word mother-fucker
2. Industry nickname for San Francisco based law firm Morrison and Foerster. The firm still uses the domain name mofo.com for its IP network services. The firm actually rebranded itself MoFo for a while until it realized that the strategy was less than successful.
John just got a job over at mofo after graduating from Law School.
mofo by mlu December 28, 2005