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To 'Base Up' refers to one of three things.

1. The application of hand sanitizer (from the base to the tip, hence the name) to ones genitals before or after a particularly questionable bout of intercourse (though a post-coital 'base up' is less likely to result in unwelcome friction).

2. In reference to the sexual encounter itself, whereby you engage in risky business and will likely require the application of 'Base Up' in the near future.

3. As a noun referring to the sanitiser itself.
"I didn't use a condom, better base up"
"Should we base up before going to the clubs?"
"Who used all the base up?"
Base Up by Power Wine January 2, 2012
When two bros are stationed at separate military bases, but are attempting to get stationed together.
Dude, when we base-up we'll get into all sorts of shit together.

I'm telling you, we're gonna rip it up as a wingman duo.
Base-Up by D audi March 12, 2012

base me up 

When a girl can/should get to the base of ones cock
base me up by Fizzle87 September 19, 2016

Fucked up the base 

When a person or situation, automatically or on purpose blocks the graft a man has put on a female to get sex. Very much like a cockblock
My flat mate won't leave the house now he's.....Fucked up the base