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An popular example of shipping in My Little Pony: Friendship is Magic, in which Twilight Sparkle and The Great and Powerful Trixie are paired together.

Its extremely high profile is due to its main proponent, Sethisto, running the central Friendship is Magic fansite, Equestria Daily.
"Twilight galloped away, tears welling in her eyes, running for the one pony whom she truly could trust. The door of Trixie's caravan slammed open, and the blue unicorn looked up in surprise; but a glance at Twilight's face explained everything. Without saying a word, she reached a hoof up to Twilight's neck and pulled her close. As the storm raged on outside, Twilight, at last, felt safe."

"Awesome story! I love Twixie!"
Twixie by RatManBatMan August 23, 2011
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The most gamer gamer on planet earth who is super hot and amazing. (you should simp for her)
"Man, Twixie sure is hot. I think I will ask Twixie out on a date."
"B-but I like Twixie!"
Twixie by Twoxer Geaminege August 20, 2021

Twixie Stick 

Replacing the tobacco from a cigar and putting Crack as the ingested substance of choice.
I got so faded last week at that party from that twixie stick.
Twixie Stick by DJ LIL NICKA August 17, 2016

phoenix/twixie 

phoenix is a horrible person who manipulates and takes advantage of people for no reason, and ruins peoples lifes, especially people who were their closest bestfriend in the past.
i died inside the day phoenix decided she would hurt me

phoenix/twixie means your a shit person<3
Pronounced (TRICK - SEE)

seeBrings happiness and Joy. A very rare name for a very unique but special personality. She is quirky, hilarious and bubbly and is very good friend to have!
“ Are you friends with that Trixie girl, I heard she’s bare funny”

“Yh I was with her yesterday, Trixie is the funniest person ever no fucking cap!”

Trixie Mattel 

Trixie Mattel (Brian Furkus) is beloved drag queen from Milwaukee, Wisconsin. Now living in WEHO. She appeared on RuPauls Best Friend Race season 7 and All Stars 3, in which she won All Stars 3 (rightfully so). She also has a hit TV show on Viceland with fellow Drag Race alumnus Katya Zamolodchicova. She uses over the top makeup skills to look like a doll.
Trixie Mattel didn't rob Shangela of the All Stars 3 crown.

Lincoln Park Trixie

A post-sorority girl in her early to mid-twenties, sports a Coach purse, oversized glasses and “Juicy” valor, seen en route to yoga (the easy kind), the day spa, shopping and then to Starbucks for a no whip, no foam, skim latte. She drives a Jetta (while sending a text message) to-and-from her overpriced studio apartment in Chicago’s Lincoln Park. Come sun-down, she scours the bars, Apple-Tini in hand, for a fiancé in the form of a day-trader, I-Banker or any other 6 figure income, generally named Chad or Todd and sporting a striped shirt.
Tad just proposed to some Lincoln Park Trixie he has known for 6 months. Yea the same one he met at a bar and cried for an hour when she spilled her Cosmo on her Coach purse.
Lincoln Park Trixie by L. Graff February 25, 2008