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OFIFU is the acronym of the phrase "Oh Fuck I Fucked Up".
It can be used in replacement for your friends name when they do something stupid aka fuck up!

This also can be molded into various forms:

Ofifian: a race of people who fuck up
Ofifed or Ofifud: both the verb form of Ofifu
"fucking ofifu, your such a dumb bitch!"
"I think victor is a ofifian he is always fucking up"
"Dick my condom rip when i was in this bitch i ofifed.
OFIFU by Arzebby June 14, 2011
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The gasping noise commonly used in animes as a reaction to astonishing beauty, especially Saiki K.
Teruhashi’s beauty made the new transfer student say “offu”.
Related Words
OFIFU offu offunsive Offurn offurselfjade Offused Offutt OFIF OFIFI Orifuu
OH! that dude just whipped out his pappy and pulled on OFFUTT on that ho!
Offutt by ricky bobbysfds January 15, 2008

offunsive 

Highly disparaging remarks, comments and jokes made in the name of fun.
People often take offense to the offunsive when they do not see the fun and humor in their folly.
Osifu is a condensed way to say "oh s***, I f***ed up." It was started by Levi Kimber and Jacob Bakko in the year 2013.
I had an osifu moment.
Levi just osifued.
osifu by bobdawkinsodst August 11, 2015
Oh F*** it's Friday. This is the opposite of TGIF. OFIF is the sinking feeling you get as your realise it is the last Friday of your holidays.
Spock: Hey Jim, why so blue.
Jim: OFIF, back to work on Monday.
OFIF by DrGee August 22, 2011
Orifuu is a great streamer on Twitch. They play mostly minecraft/bedwars, but also build in creative. They have played on some SMPs but their bedwars streams are always the best.
Have you ever heard of Orifuu?
No, who are they?
They're a streamer on Twitch and I love their streams!
Orifuu by therealonetwice January 1, 2022