1. the sum of unpleasant physiological effects following heavy consumption of drugs, particularly alcoholic beverages.
usually seen on the face. is worse with excessive sun, smoking, poor diet and hydration practices, other physical problems/illness related, lack of sleep.
2. any part of a person's body that is particularly worn and 'used up'.
she was a student/athlete in high school but she's looking pretty shot out now.
that girl is shot out, she's slept with everyone and a few of the moms.