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The number 528491 is a series of random digits that Robert Fischer gives to the team. In the City dream, Cobb demands the first six digits that come into Fischer's mind, telling him that they may be the password to a safe containing his father's alternate will. In reality, Cobb's team just needs Fischer to invent a password to the safe where his subconscious hides his secrets.
In the Hotel, the team sleeps in room 528, and Arthur sets explosive charges beneath them in room 491

In the Hotel, when Eames, disguised as Blonde, gives a number to Fischer it has six digits: 528-491.

In the Mountain, Fischer opens the safe with the numbers 528491.
by inceptionwiki December 19, 2010
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