1. noun. Any medication taken to lessen the effects of depression. The drugs relieve the sense of hopelessness that accompanies depression, thus hope; however, they are mood-altering chemicals that may produce side effects and addiction, thus dope.
- Jillian's doctor gave her some hope dope to keep her from trying to kill herself again.
- When John goes off his hope dope, he pukes, shivers, and wants to die.