New York City underground drug slang used to refer to cocaine. Usually used in the context when describing the severity of a "comedown". Also used contextually in public, using metaphorical references pertaining to a grandmother, but reffering to cocaine usage.
Wow. Grandma was such a bitch last night! She promised love and her cookies, but when I tried to go to sleep she kept banging pans in the other room. That bitch kept me up all night. Grandma is a dirty bitch from hell!