It's a subtle way of saying that you can't do something in a relationship. Like when you don't have time for a romantic dinner, but only two minutes for sex.
Woman: We're supposed to taste wedding cakes this afternoon, remember?
Man: Ouch! No-can-do's-ville, baby doll.
Woman: Wow, that was really mean. I think you owe me an apology.
Man: No-can-do's-ville, baby doll, no-can-do's-ville.