An American President can achieve a "FDR Hat Trick" if they experience an economic crisis and a war, all while having a debilitating disease, during his or her time in office.
FDR went through the Great Depression, and World War II, and remained one of the most accomplished presidents even though he had polio, and scored himself a FDR Hat Trick.
The only other president to have an FDR Hat Trick was President George W. Bush
, who led the nation through Iraq
, through an economic clusterfuck
, but was elected even though he is mentally retarded