1 definition by Take that Jack

OB
Short for Oh Brother.

Usually said in conversation when wanting to express emotions of exasperation.
Liz Lemon (30 Rock): (Rolls eyes) "Ohh brother"

Weirdo: "OMG don't you dare put that on fb.. I look soooo fat! Delete it now! DELETE IT!"

Denise/Justine/Trish: "OB!"
by Take that Jack October 31, 2009

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