1 definition by StoningStoner

The word, "Sho", can mean many things. It can be used to agree with someone. Originating most likely as follows, (For sure>foe show>fo sho>sho>Sho!). When saying "sho", you can't say it quietly or else it loses it meaning.

Sho can also be used to say no. Or even goodbye and many other things. Drugs are usually involved when people say sho. It depends on your tone and volume when saying the word.
Guy 1: "Yo! Guy 2! Look at that girl! She fine!"
Guy 2: "Sho!"

Guy 1: "Guy 2! Wanna smoke a jay later?"
Guy 2: "Watch you think? Sho!"
Guy 1: "Sho! See yah then!"
Guy 2: "Sho!!"
by StoningStoner August 24, 2011
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