1 definition by Smart Nigga 18

Top Definition
a confusing and impossible to understand situation or place. Very complex. Only nerdy niggas will have a chance to understand a mysterium. Everybody else don't even try, your head will explode.
James: "Yo Will, girls are a mysterium. I'm trying to figure out why they crazy as hell"
Will: "You better stop man before your head explodes. Shit's crazy"
by Smart Nigga 18 July 26, 2008
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