1 definition by Prime Dean

I.S.

Pronounced ‘Aiy’ ‘Ess’
Short for Infatuated Spaz. A person who is so besotted by someone that they don’t mind being verbally or physically abused by them.

“Hey man you really shit on your girl don’t you?”
“Don’t worry about her she’s my I.S.

by Prime Dean July 29, 2018