Not so much a blunt statement as it is a motto in life. This simple yet profound observation states what we all think about bitches and their ways and sums up into simple terms the craziness that they be.
Not all women are bitches, and not even all bitches are women, but the bitches that be are, in fact, crazy.
The correct reply upon hearing this is to echo it back in confirmation.
guy1: Last week my ex scratched a giant cock onto the side of my car, and just today I got a text from her asking me to take her back.... the fuck?!?
guy2: Dude, bitches be crazy.
guy1: Bitches be crazy.