noun. "Hot tranny mess" was coined in 2008 by Christian Siriano, an American fashion designer and the winner of the fourth season of American reality show Project Runway. His remark incensed the transgendered community. He soon apologized for the remark.
The term is now used to describe generically anyone (regardless of sexual identity) who is any of these: a fashion nightmare, a bad dancer, sloppy drunk, has atrocious manners, tells hilarious off-color jokes, is very funny, is flamboyant, or whose life is in shambles or an endless comedy of errors.
Who is that hot tranny mess getting thrown out of the bar?
Oh, my God! That's too funny! You crack my ass up, you hot tranny mess!