1. past part. of spiff (to groom or make attractive) usu. spiffed up; also, well-dressed
2. Intoxicated esp. to a level of severely impaired motor and cognative function, usu. from ingestion of alcohol or alcohol in conjunction with other illicit/illegal drugs
1. "My dentist really spiffed up his waiting room over the summer!" or "My roommate spiffed up for his date tonight."
2. "After four shots and six beers, I was so spiffed I couldn't stand up." or "I was a little drunk when we got to her place, but after we smoked a couple bowls I was totally spiffed!"