1 definition by JessiBella.

used in the midwest area, beef is when you say something about someone, and they are the "punchline" of your joke.
Jessica: Bitch your breath stank like shit!!

Rick: Damn hoe, why you beef me like that.

Jessica: Ahaaaa. Im Honest.

**could also use beefing or beefin.
by JessiBella. March 8, 2009
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