1. hitting on someone with the intention of hooking up
2. drinking to excess with the purpose of getting fubar
3. getting high
4. a compliment; a sexy bitch/ beast
1. 'dayum, that girl is fine! i'ma go lock it down'
2. 'i got a 5th of stoli, i'ma lock it down'
3. 'it's 4:20, let's blaze this shit up!'
4. 'sup, how long you been lockin' it down'
'dayum, that guy is lockin' it down!'