A Sick Shot is a shot that one takes in his mouth. Most of the time the shots taken are from other men, however animals are sometimes included. Sometimes, the shots will be taken out of shot glasses as well and may be video taped to be streamed on porn sites. A Sick Shot is a degrading way of saying "You sir, are a fag".
Also, a sick shot can be an STD ridden 16 year old who stinks of rejection and bordom and doesn't have a clue about life.
"Hey, remember that one kid? I heard he took a sick shot in the bathroom!"
"No way! What a sick shot!"