A variation on the word "whore", stemming from a regional North American pronunciation of the same word.
Cited by the case U.S. v. Murphy in the 7th Circuit Court of appeals on page 2, footnote 1
"The trial transcript quotes Ms. Hayden as saying Murphy called
her a snitch bitch “hoe.” A “hoe,” of course, is a tool used for
weeding and gardening. We think the court reporter, unfamiliar
with rap music (perhaps thankfully so), misunderstood Hayden’s
response. We have taken the liberty of changing “hoe” to “ho,” a
staple of rap music vernacular as, for example, when Ludacris
raps “You doin’ ho activities with ho tendencies.”
"why do you think you take a ho to a hotel?
Hotel everybody, even the mayor
Reach up in tha sky for tha hozone laya
Come on playa once a ho always
And hos never close they open like hallways
An heres a ho cake for you whole ho crew
an everybody wants some cuz hoes gotta eat too"
--From "You a Ho" by Ludacris