1 definition by Dr. Underthere
A serious illness often causing death within the first month of infection. It is not a laughing matter and should be treated with absolute caution. Those that have it often experience symptoms such as build-ups of Ligma, constant Sugma release, finding a unique interest in tapes and CD's, and anal inflammation.
"Why is Aidan not in School?"
"I heard he has Updog disease."
"Oh my god, that is terrible and not a joke in any way"
"I heard he has Updog disease."
"Oh my god, that is terrible and not a joke in any way"
by Dr. Underthere March 10, 2020